CCD-d ristreaktiivne karbohüdraadi determinant Cross- reactive Carbohydrate Determinant Stabiilsed proteiinid MUXF3 CCD, bromeliin Laialt esindatud taimedel ja selgrootutel loomadel Kliinilisi sümptomeid põhjustavad harva, sage ristreaktsiooni põhjustaja, üksikutel patsientidel võib tekkida raske allergiline reaktsioon nt. Sumitomo Sumitomo Chemical Company Ltd of Osaka and Tokyo is one of Japan's largest chemical manufacturers, with a product range including basic chemicals, petrochemicals, fine chemicals, agricultural chemicals and pharmaceuticals. The next step was to be the complete merger of the two parent companies. Cor a 8 on stabiilne komponent, ristreaktiivne virsiku primaarallergikutel. It also provided further documents on folic acid, and on 10 January provided a response to a request for information in relation to folic acid, sent on 15 November
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- Views: Transcription 1 Allergia molekulaarne diagnostika Osakond: kliiniline immunoloogia, tel Üldiseloomustus Siiani kasutuses olev traditsiooniline allergia diagnostika põhineb natiivallergeeenide ekstraktidel.
- VITAMINS 3 Vitamins are a group of micronutrients of various types of organic compounds required in small amounts in human and animal diet for normal growth, development and maintenance of life.
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Sagedased ristreaktsioonid pähklite ja seemnete erinevate liikide vahel. Ristreaktsioonide sagedus tõuseb vanusega. CCD-d ristreaktiivne karbohüdraadi determinant Cross- reactive Carbohydrate Determinant Stabiilsed proteiinid MUXF3 CCD, bromeliin Laialt esindatud taimedel ja selgrootutel loomadel Kliinilisi sümptomeid põhjustavad harva, sage ristreaktsiooni põhjustaja, üksikutel patsientidel võib tekkida raske allergiline reaktsioon nt.
Kliinilise immunoloogia osakonnas alustasime spetsiifilise IgE määramist järgmiste allergeenikomponentide suhtes: 1. Toiduallergeenide komponendid - Piim f2Bos domesticus f78 n Bos d 8 kaseiin Enamus piimaallergikutest on allergilised mitmele piimaallergeeni komponendile korraga.
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Enamus lapsi talub 4 B12 Trading System piima. Kõrge kaseiini ja β- laktoglobuliini Bos d 5 vastaste IgE antikehade tase viitab jäävale allergiale ja suuremale süsteemse reaktsiooni riskile.
Proteiinide allergeensus ei vähene termilisel töötlemisel ega seedeprotsessis. Kliiniline sümptomaatika on peamiselt lokaalne. Cor a 1 on ristreaktiivne ka teiste õietolmude ja toidutaimedega, kus esineb PR valk. Cor a 8 on stabiilne komponent, ristreaktiivne virsiku primaarallergikutel. Võimalikud nii kerged kui rasked allergilised reaktsioonid. Annab ristreaktsiooni kõigi toidutaimedega, mis sisaldavad nt LTPs. Munavalge dominantne allergeen, kuumakindel, resistentne seedeensüümidele.
Kõrge Gal d 1 IgE tase viitab süsteemse allergilise reaktsiooni riskile ja madal IgE tase või IgE puudumine tolerantsi kujunemisele munaallergia korral võimalik tarvitada keedetud muna.
Gly m 4 on ristreaktiivne labiilne marker kaseallergia korral, enamasti B12 Trading System kerge allergiline reaktsioon, harva raske 5 OAS. Gly m 4 on ristreaktiivne ka Ara h 8 ja kõigi PR valku sisaldavate õietolmude ja taimsete viljadega. Up to it was part of the Philips industrial group. It produces pharmaceutical drugs for human use.
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The only vitamin it produces and sells is vitamin D3. It is established as the operating subsidiary of E. Merck oHG. Merck oHG now acts purely as a holding company. Merck's relevant products for the purposes of this procedure are vitamins C and H biotin.
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Daiichi Daiichi Pharmaceutical Co. Ltd of Tokyo, Japan, was founded in and produces a wide range of ethical pharmaceuticals, over-the-counter health products and veterinary products. Daiichi's relevant vitamin production is in vitamins B5 calpan and B6. Eisai Eisai Co. Ltd of Tokyo is a leading Japanese pharmaceutical and drug manufacturer specializing in ethical drugs.
The only relevant product for present purposes is folic acid. Sumitomo Sumitomo Chemical Company Ltd of Osaka and Tokyo is one of Japan's largest chemical manufacturers, with a product range including basic chemicals, petrochemicals, B12 Trading System chemicals, agricultural chemicals and pharmaceuticals. The relevant product for present purposes is folic acid. Takeda Takeda Chemical Industries Ltd, also of Osaka, and incorporated inis engaged in industrial chemicals, drugs, cosmetics and healthcare products and is a leading manufacturer of pharmaceuticals operating on a global basis; it is the principal vitamin producer in Japan and also one of the main producers of bulk vitamins worldwide.
Tanabe Tanabe Seiyaku Co. Ltd of Osaka is one of the leading pharmaceutical producers in Japan.
Tanabe buys in other bulk vitamins from other producers, including Roche vitamins B1 and C and either uses them in its downstream production or resells them as a trader. The second column shows data for the worldwide turnover in the vitamin product concerned in the last complete calendar year of the infringement and, in brackets, the range of the company's market share in the worldwide market concerned during the time period of the infringement.
The third column shows the same information as that of column two but in relation to the EEA-wide vitamin product market instead of the worldwide market. All of these figures are necessarily approximate.
They informed the Commission of their intention to cooperate with any investigations, but without at the time providing any statement or documentary evidence. These statements Kauplemisstrateegia ei toota covered the vitamin products which were the subject of the prosecutions in the United States of America.
As regards pre-mixes, the producers claimed that while there had been sporadic discussions on pre-mix in Europe, there had never been any effective agreements for this format, since most sales were made as "straights" The requests did B12 Trading System relate to all the products in respect of which collusion on their part was suspected Takeda claimed it had already prepared the file before receipt of the Article 11 request. It provided a reply to the request for information on 18 and 20 October concerning vitamins B1 and B6.
It also provided further documents on folic acid, and on 10 January provided a response to a request for information in relation to folic acid, sent on B12 Trading System November On 22 November it provided certain relevant documents regarding the B12 Trading System in that product. The Commission provided a full copy of all accessible and partially accessible documents in its file of the case, including non-confidential versions of partially accessible documents, B12 Trading System the CD-ROM which was provided to all addressees of the statement of objections.
A descriptive list of the content of the non-accessible documents was established and provided to the same addressees. At the Oral Hearing the undertakings were also given the opportunity to comment on the written replies of the other parties which had been made available to them earlier. Certain individuals were also charged with criminal violations of the Sherman Act. The vitamins and time periods concerned were as follows: - vitamins A and E: from January to February- vitamin B2: from January to at least Fall- vitamin B5: January to at least December- vitamin C: from January to at least Fall- beta-carotene: from January to at least Decemberand - vitamin pre-mixes: from January to at least December Two of the most senior executives of Roche, Messrs[ The origin and basic scheme of the cartels The European producers state that prices for both vitamin A and E actually fell significantly during the late s as a result of competition.
The "dramatic" fall in price in vitamin E is attributed by Roche to the "price offensive" of Eisai in for vitamin A, Roche blames the aggressive pricing policy of Rhône-Poulenc.
The meeting lasted two days. Eisai did not attend; Roche says the idea was to bring Eisai in at a second stage. Market shares were frozen at levels; as the market expanded, each company could increase its sales only in accordance with its agreed quota and in line with market growth and not at the expense of a competitor.
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The maxim "price before B12 Trading System was accepted as the underlying principle of the cartel. Specific pricing levels were also discussed. For each region, including Europe, the market share quotas were further broken down country by country, so that the total of the allocations corresponded with the regional share assigned and the regional shares added up to the world quotas. Structure and participants Structure of regular meetings As the implementation of the cartel developed, a complex structure of regular meetings evolved.
There were four levels. Top level This level was constituted by the most senior corporate officers with responsibility for the vitamins business, and included the divisional heads and sometimes the heads of vitamins marketing. Their role was to back the agreement with high-level support, to define overall strategy and ensure each party continued to adhere to the agreement.
Heads of marketing The heads of vitamins marketing, who might also attend the top level meetings, took decisions on the practical operation of the agreements and finalised the budgets.
Some of their meetings might also be attended by the divisional chairmen. B12 Trading System met two or three times per year.
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Global product marketing level This level consisted of managers with product marketing responsibility for vitamins A and E at global level. Their meetings, held at quarterly intervals, were intended to monitor the implementation of the quota systems. Regional product marketing level These meetings, which were organised by the regional management and involved the heads of marketing for each region, including Europe, were held about four times a year.
Discussions included pricing to individual customers. The group was also responsible for: - monitoring sales against budget on a regional level and making adjustments if necessary; - identifying relevant market developments inside their region; - implementing the B12 Trading System increases agreed at the more senior levels. The interaction between the different groups The cartel's operations centred on the preparation and implementation of the annual "budget".
Indeed in this and other respects its mechanisms were closely modelled on the internal financial management and controls of a single undertaking.
According to Rhône-Poulenc, Roche first made a presentation on the current state of the market with tables prepared from the information which the others had provided in advance by telephone. Final decisions on pricing were usually taken in the second half of the year, a typical effective date for an increase being 1 April of the following year. Apparently however, it occasionally asked BASF to lead the increase publicly.
At the meetings, which were organised and led by Roche, Roche presented market developments and the Division Chairmen would discuss the size of the market, increases in market shares, price movements and resolve potential problems. According to Rhône-Poulenc, there was no specific agenda. These are however presumably the meetings described by Roche. Their purpose was to demonstrate top-level support for the cartel and to determine overall strategy.
These meetings were scheduled B12 Trading System the month following the end of each quarter. The regional marketing managers reported on market developments to the more senior level of meetings which took the necessary decisions.
Every month they exchanged the volumes of vitamins A and E sold in each national market.
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Roche provided the others with the monthly sales of Eisai in the European market as a whole rather than for each country. Volume control mechanism: "budgets" General The fundamental idea underlying the cartel was to freeze market shares in both products at the level. For the most part, the BASF documents consist of a worksheets or support documents used to fix the annual "budget" for each producer on a country-by-country basis and b charts comparing the actual sales of each producer with their respective "budgeted volumes", i.
If at the end of the year a producer was substantially ahead of its quota, it had to purchase vitamins from the others in order to compensate them for the corresponding shortfall in their allocation.
Vitamin E A similar computerised database was kept for vitamin E, although 1 there are separate charts for "feed", "pharmaceutical" and "total" and 2 the volumes are given in metric tonnes. Minimum and target prices In their "top-level" meeting in Zurich in Septemberthe divisional chairmen of Roche, BASF and Rhône-Poulenc had agreed to a policy of "price before volume".
Final decisions were generally taken in the second half of each year with a typical effective date for the "increase" being the following 1 April. Once the price increase was announced by one cartel member, the others would generally follow suit. Operation of the cartels to During the first year of the cartel, executives from Roche, BASF and Rhône-Poulenc B12 Trading System frequently to concretise their arrangements: Rhône-Poulenc has identified some nine meetings in Basel between January and January Proovi tellimuse tugi.
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